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AI in Personalized Medicine: Tailoring Treatments to Individual Genetic Profiles with Machine Learning

© 2023 by IJACT

Volume 1 Issue 1

Year of Publication : 2023

Author : Manoj Boopathi Raj, Sneha Murganoor

:10.56472/25838628/IJACT-V1I1P111

Citation :

Manoj Boopathi Raj, Sneha Murganoor, 2023. "AI in Personalized Medicine: Tailoring Treatments to Individual Genetic Profiles with Machine Learning" ESP International Journal of Advancements in Computational Technology (ESP-IJACT)  Volume 1, Issue 1: 82-95.

Abstract :

Personalized medicine is a concept shifting from a conventional system of patient treatment to patient-specific genetic and phenotypic variations. Modern technologies in sophisticated artificial intelligence and machine learning in the healthcare industry have enhanced the possibility of making tailored treatments depending on a client’s genetic makeup. This paper is going to examine the roles of AI, ML and personal medication with a view to analyzing how these technologies are implemented to personalize medicine. In specific, the study gives back and takes a look at different AIMS models, including supervised learning, deep learning and reinforcement learning, that are used in the area of PM to forecast patients’ prognosis, diagnose ailments and recommend the most suitable treatments. Neural network is one of the advanced AI techniques which are capable of functioning on large-scale genomic data and screening out the mutations or biomarkers associated with the diseases. Artificial intelligence also presents capabilities to identify correlations from genomic information that may be used in identifying disease susceptibility, drug reactions or complications from a particular disease. We explain how methodology based on machine learning allows clinicians to identify the likelihood of drug effectiveness and toxicity and, therefore, set more precise routes. In addition, through the help of AI, it enhances pharmacogenomics, the study of genetic factors that influence drug response, making it easier to prescribe doses and treatment plans. Despite the potential that AI in personalized medicine, there are numerous barriers, including data privacy, integration into clinical practice, model interpretability and many more that are still emerging. Cancer, cardiovascular diseases, neurological disorders, and rare genetic makeups are some of the easily recognizable areas that the paper, using case studies and recent developments, seeks to establish how AI is being applied in identifying the treatment channels. Finally, this paper gives a future prospect on the part that artificial intelligence will play in the future execution of health enhancement.

References :

[1] Esteva, A., Robicquet, A., Ramsundar, B., Kuleshov, V., DePristo, M., Chou, K. & Dean, J. (2019). A guide to deep learning in healthcare. Nature Medicine, 25(1), 24-29.

[2] Shickel, B., Tighe, P. J., Bihorac, A., & Rashidi, P. (2017). Deep EHR: a survey of recent advances in deep learning techniques for electronic health record (EHR) analysis. IEEE journal of biomedical and health informatics, 22(5), 1589-1604.

[3] He, K., Zhang, X., Ren, S., & Sun, J. (2016). Deep residual learning for image recognition. In Proceedings of the IEEE conference on computer vision and pattern recognition (pp. 770-778).

[4] Liu, B., He, H., Luo, H., Zhang, T., & Jiang, J. (2019). Artificial intelligence and big data facilitated targeted drug discovery. Stroke and vascular neurology, 4(4).

[5] Vamathevan, J., et al. (2019). "Applications of Machine Learning in Drug Discovery and Development." Nature Reviews Drug Discovery, 18, 463-477.

[6] Sebastiani, M., Vacchi, C., Manfredi, A., & Cassone, G. (2022). Personalized medicine and machine learning: a roadmap for the future. Journal of Clinical Medicine, 11(14), 4110.

[7] Cruz, J. A., &Wishart, D. S. (2006). "Applications of Machine Learning in Cancer Prediction and Prognosis." Cancer Informatics, 2, 59-77.

[8] Kumar, R. (2021). AI in Personalized Medicine: Tailoring Treatments to Individual Patients. AI Applications in Healthcare, 3(3).

[9] Schork, N. J. (2019). Artificial intelligence and personalized medicine. Precision medicine in Cancer Therapy, 265-283.

[10] Blasiak, A., Khong, J., & Kee, T. (2020). CURATE. AI: optimizing personalized medicine with artificial intelligence. SLAS TECHNOLOGY: Translating Life Sciences Innovation, 25(2), 95-105.

[11] Awwalu, J., Garba, A. G., Ghazvini, A., & Atuah, R. (2015). Artificial intelligence in personalized medicine application of AI algorithms in solving personalized medicine problems. International Journal of Computer Theory and Engineering, 7(6), 439.

[12] Ivanovic, M., & Semnic, M. (2018, November). The role of agent technologies in personalized medicine. In 2018 5th International Conference on Systems and Informatics (ICSAI) (pp. 299-304). IEEE.

[13] Ortega, V. E., & Meyers, D. A. (2014). Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine. Journal of allergy and clinical immunology, 133(1), 16-26.

[14] Offit, K. (2011). Personalized medicine: new genomics, old lessons. Human genetics, 130, 3-14.

[15] Dunn, J., Mingardi, L., & Zhuo, Y. D. (2021). Comparing interpretability and explainability for feature selection. arXiv preprint arXiv:2105.05328.

[16] Silva, V. S., Freitas, A., & Handschuh, S. (2019). On the semantic interpretability of artificial intelligence models. arXiv preprint arXiv:1907.04105.

[17] Huang, S., Yang, J., Fong, S., & Zhao, Q. (2020). Artificial intelligence in cancer diagnosis and prognosis: Opportunities and challenges. Cancer Letters, 471, 61-71.

[18] Dack, E., Christe, A., Fontanellaz, M., Brigato, L., Heverhagen, J. T., Peters, A. A., ... & Ebner, L. (2023). Artificial intelligence and interstitial lung disease: Diagnosis and prognosis. Investigative radiology, 58(8), 602-609.

[19] Pei, Q., Luo, Y., Chen, Y., Li, J., Xie, D., & Ye, T. (2022). Artificial intelligence in clinical applications for lung cancer: diagnosis, treatment and prognosis. Clinical Chemistry and Laboratory Medicine (CCLM), 60(12), 1974-1983.

[20] Kumar, S., Kumar, H., Agarwal, R., & Pathak, V. K. (2022). Human disease prognosis and diagnosis using machine learning. In Emerging Technologies for Computing, Communication and Smart Cities: Proceedings of ETCCS 2021 (pp. 41-53). Singapore: Springer Nature Singapore.

Keywords :

Artificial Intelligence (AI), Machine Learning (ML), Personalized Medicine, Genomic Data, Pharmacogenomics, Precision Medicine, Predictive Analytics, Deep Learning.