Citation :

Tukur Mukhtar, Mudassir Abubakar, Buhari Y. Idris, Ismail Lawal, Abubakar D. Nasiru, Abdullahi Salihu, 2023. "Phytochemical and Synergistic activities of Tapinanthusglobiferus Growing on Tarminalia Catappa with Amoxicillin" ESP International Journal of Advancements in Science & Technology (ESP-IJAST)  Volume 1, Issue 3: 7-11.

Abstract :

When combined in a certain ratio, the effects of ampicillin and tapinanthusglobiferus demonstrated relevance in the treatment of diseases caused by Epulopiscium spp.The purpose of this study was to use broth microdilution and checkerboard techniques to examine the phytochemical content and assess the synergistic effects of amoxicillin and methanol leaf extract of T.globiferus grown on Tarminalia catappa against bacterial isolate.Amoxicillin demonstrated a minimum inhibitory concentration (MIC) of 10 mg/mL against the test organism, whereas T. globiferus displayed a MIC of 25 mg/mL. While ratios (6:4 and 5:5) with fractional inhibitory concentration (FIC) index 1.2 and 1.5 indicated indifference against the test organism, other ratios (9:1, 8:2, 7:3, 4:6, 3:7, 2:8, and 1:9) with fractional inhibitory concentration (FIC) index of 0.56, 0.60, 0.65, 0.8, 0.85, 0.9, and 0.95 demonstrated synergism upon combination. This study's findings indicated that certain ratio combinations may be indifferent or synergistic.Phenolic, saponnins, tannins, flavonoids, steroids, and terpenoids were found in the methanol leaf extracts of Tapinanthus globiferus growing on Tarminaliacat, according to a preliminary phytochemical screening. The plant has an antibacterial effect and can therefore be used to treat diseases caused by Epulopiscium spp. The minimum inhibitory concentration (MIC) of the extract revealed that the plant's methanol extract could inhibit the growth of Epulopiscium spp. at a concentration of 25 mg/ml.

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Keywords :

Phytochemical Screening, Synergy; Amoxicillin, Tapinanthusglobiferus.